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Systemic Diseases

56
Publications
53.57
%Q1
135
Number of citations
60.47
% Open Access Publications
13
Ongoing Projects
5
Number of Presented Theses
52
Number of Active Clinical Trials
Our team has continued working on autoimmune diseases and autoinflammatory disorders. Studies focusing on the role of disturbances among immune cells, cytokines and autoantibodies and their relationship with recurrent pregnancy loss and inflammatory placental-related disorders are ongoing. Animal models and trophoblast organoids and the role played for aPL and chronic stress on poor obstetric outcomes have been included in this research. The relationship between myositis and systemic sclerosis and cancer, as well as different autoantibody profiles, were analysed. Recent reported autoimmune diseases in oncologic patients treated with check point inhibitors have also focused our interest. Gene-wide genetic and molecular signatures in systemic vasculitis, Sjögren syndrome and systemic sclerosis to find relationship with clinical subsets have been studied. We described a new risk haplotype for developing autoimmune/granulomatous disorders in women with breast implants.  

eCORE

  • Woman & Child Health & Rare Diseases

Team

Group Leader
Jaume Alijotas Reig

Principal Investigator (PI)
Victoria Cardona Dahl, Moisés Labrador Horrillo, Albert Selva O'Callaghan, Carmen Pilar Simeón Aznar, Mª Roser Solans Laqué, Francesc Miró Mur

Researchers
Enrique Esteve Valverde, Albert Gil Vila, Mar Guilarte, Alfredo Guillén del Castillo, Olga Luengo, Fernando Martínez Valle, Jaume Mestres Torres, Josep Pardos Gea, Anna Sala Cunill

PhD Students
Ariadna Anunciación Llunell, Joana Marques Soares

Lab Technicians
Laura Donaire Lancharro, Nataria Pozuelo Ventura

Selected Publications

Alijotas-Reig J, Anunciacion-Llunell A, Esteve-Valverde E, Morales-Pérez S, Rivero-Santana S, Trapé J, González-García L, Ruiz D, Marques-Soares J, Miro-Mur F.
Pituitary-Adrenal Axis and Peripheral Immune Cell Profile in Long COVID
Biomedicines. 2024 Mar 5;12(3):581
DOI: 10.3390/biomedicines12030581.
IF: 3.9

Gil-Serrano J, Labrador-Horrillo M, Galvan-Blasco P, Sala-Cunill A, Bigas P, Pereira-González J, Luengo O, Cardona V, Guilarte M.
Systemic inflammation biomarkers during angioedema attacks in hereditary angioedema
Front Immunol. 2024 Jun 17;15:1400526
DOI: 10.3389/fimmu.2024.1400526.
IF: 5.7

Perurena-Prieto J, Viñas-Giménez L, Sanz-Martínez MT, Selva-O'Callaghan A, Callejas-Moraga EL, Colobran R, Guillén-Del-Castillo A, Simeón-Aznar CP.
Anti-nuclear valosin-containing protein-like autoantibody is associated with calcinosis and higher risk of cancer in systemic sclerosis
Rheumatology (Oxford). 2024 Aug 1;63(8):2278-2283
DOI: 10.1093/rheumatology/kead520.
IF: 4.7

Pinal-Fernandez I, Muñoz-Braceras S, Casal-Dominguez M, Pak K, Torres-Ruiz J, Musai J, Dell'Orso S, Naz F, Islam S, Gutierrez-Cruz G, Cano MD, Matas-Garcia A, Padrosa J, Tobias-Baraja E, Garrabou G, Aldecoa I, Espinosa G, Simeon-Aznar CP, Guillen-Del-Castillo A, Gil-Vila A, Trallero-Araguás E, Christopher-Stine L, Lloyd TE, Liewluck T, Naddaf E, Stenzel W, Greenberg SA, Grau JM, Selva-O'Callaghan A, Milisenda JC, Mammen AL
Pathological autoantibody internalisation in myositis
Ann Rheum Dis 2024, Oct 21;83(11):1549-1560.
DOI: 10.1136/ard-2024-225773
IF: 20.3

Solans-Laqué R, Rúa-Figueroa I, Blanco Aparicio M, García Moguel I, Blanco R, Pérez Grimaldi F, Noblejas Mozo A, Labrador Horrillo M, Álvaro-Gracia JM, Domingo Ribas C, Espigol-Frigolé, G, Sánchez-Toril López F, Ortiz Sanjuán FM, Arismendi E, Cid MC
Red flags for clinical suspicion of eosinophilic granulomatosis with polyangiitis (EGPA)
Eur J Intern Med. 2024 Oct;128:45-52.
DOI: 10.1016/j.ejim.2024.06.008
IF: 6.0

Selected Projects

Identificación de biomarcadores celulares y moleculares en angioedema idiopático y hereditario para su diferenciación en fenotipos y endotipos
Principal Investigator: PI: Mar Guilarte Clavero, CO-PI: Moisés Labrador Horrillo
Agency: AES. Proyectos de Investigación en Salud
Funding: 84,700 €
Period: 01/01/2021 - 30/06/2025

Functional characterization of the genetic regions associated to systemic sclerosis (FunES)
Principal Investigator: Alfredo Guillén
Agency: Instituto de Salud Carlos III
Funding: -
Period: 01/01/2023-31/12/2025

Determinación de nuevos anticuerpos en síndrome de Sjögren.
Principal Investigator: PI: Jaume Mestre-Torres, CO-PI: R. Solans-Laqué.
Agency: Projecte AES I+D+i 2024 (FIS)
Funding: 50,000 €
Period: 2024-2027

Anticuerpos antifosfolipídicos inductores de memoria inmune innata en monocitos como causa de morbilidad obstétrica en el síndrome antifosfolipídico.
Principal Investigator: PI: Francesc Miro Mur, CO-PI: Jaume Alijotas-Reig
Agency: Instituto de Salud Carlos III (FIS)
Funding: -
Period: 2024-2027

Statin Intervention for Severe Early-Onset Placental Insufficiency: A Randomized Controlled Trial Assessing daily Administration as a Treatment Strategy (STATIN-PRE trial)
Principal Investigator: PI: Elisa Llurba-Olive, PI at VHIR: Jaume Alijotas-Reig
Agency: Fundació La Marató
Funding: -
Period: 2024-2027

VHIR Annual Report 2024