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Physiology and Pathophysiology of the Digestive Tract

35
Publications
62.86
%Q1
54
Number of citations
66.67
% Open Access Publications
13
Ongoing Projects
0
Number of Presented Theses
14
Number of Active Clinical Trials
Our research program at the Vall d’Hebron Research Institute (VHIR) and University Hospital promotes high-impact research aimed at improving public health. Integrated into VHIR’s Chronic Diseases and Aging eCORE, the group focuses on translational research in digestive diseases, including inflammatory bowel diseases, microbiota and neurogastroenterology, as well as motility and pancreatic and high-risk mucosal diseases. The program also addresses quality of life and use of health care resources, and actively participates in clinical trials from a gender and sex perspective, recognizing its importance in disease expression and therapeutic response. The group promotes citizen participation, enhancing both scientific quality and community engagement, and is active in national and international research and clinical networks, contributing significantly to scientific advances and therapeutic development.

eCORE

  • Chronic, Prevalent Diseases & Aging

Team

Group Leader
Fernando Azpiroz Vidaur

Principal Investigator (PI)
Carmen Alonso Cotoner, Natalia Borruel Sainz, Danila Guagnozzi, Beatriz Lobo Álvarez, Carolina Malagelada Prats, Xavier Molero Richart, Virginia Robles Alonso, Jorge Serra Pueyo

Researchers
Ariadna Aguilar Cayuelas, Lara Aguilera Castro, Luís Gerardo Alcalá González, Claudia Barber Caselles, Claudia Herrera de Guise, Ronald Llerena Castro, Laura Campderros Traver, Stephanie Tasayco

PhD Students
Elena Céspedes Martínez, Adoración Nieto Ruíz, Xavier Serra Ruíz, Raquel Ibañez Ferrer

Lab Technicians
Elba Expósito Fernández

Nursing and Technical Staff
Sara Mendez Soriano, Elena Oller Jiménez, Zaira Pérez, Laura Polo Figueras, Ana María Rodríguez López

Selected Publications

Fierens L, Carney N, Novacek G, van der Woude CJ, Siegmund B, Casellas F, Borruel N, Huberts AS, Sonnenberg E, Gerold N, Primas C, Hedin CRH, Stamm T, Julsgaard M, Fiorino G, Radice S, Zini MLL, Gross E, Sander C, Arijs I, Vakouftsi VR, Koltai T, Health Outcomes Observatory H O Patient Advisory Board For Inflammatory Bowel Diseases, Health Outcomes Observatory H O Steering Committee, Charlafti I, Ferrante M.
A Core Outcome Set for Inflammatory Bowel Diseases: Development and Recommendations for Implementation in Clinical Practice Through an International Multi-stakeholder Consensus Process.
J Crohns Colitis. 2024 Oct 15;18(10):1583-1595.
DOI: 10.1093/ecco-jcc/jjad195
IF: 8.3

Barba E, Livovsky DM, Accarino A, Azpiroz F
Thoracoabdominal Wall Motion-Guided Biofeedback Treatment of Abdominal Distention: A Randomized Placebo-Controlled Trial.
Gastroenterology. 2024 Aug;167(3):538-546.e1.
DOI: 10.1053/j.gastro.2024.03.005.
IF: 26.3

Livovsky DM, Barber C, Azpiroz F
Hedonic Responses to Meal Ingestion in Patients With Functional Dyspepsia and Postprandial Symptoms
Am J Gastroenterol. 2024 Nov 14.
DOI: 10.14309/ajg.0000000000003202
IF: 8.5

Izagirre A, Sarasqueta C, Flores-Arriaga J, Aso MC, Pérez Pérez M, Tack J, Huang IH, Sperber AD, Palsson OS, Bangdiwala SI, D'Amato M, Lanas Á, Lobo B, Alonso-Cotoner C, Santos J, Bujanda L.
Worldwide Prevalence and Description of Cyclic Vomiting Syndrome According to the Results of the Rome Foundation Global Epidemiology Study.
Am J Gastroenterol. 2024 Sep 25.
DOI: 10.14309/ajg.0000000000003105.
IF: 8.5

Zheng T, Roda G, Zabana Y, Escudero-Hernández C, Liu X, Chen Y, Camargo Tavares L, Bonfiglio F, Mellander MR, Janczewska I, Vigren L, Sjöberg K, Ohlsson B, Almer S, Halfvarson J, Miehlke S, Madisch A, Lieb W, Kupčinskas J, Weersma RK, Bujanda L, Julià A, Marsal S, Esteve M, Guagnozzi D, Fernández-Bañares F, Ferrer C; MC-Europe GETECCU GWAS group; Peter I, Ludvigsson JF, Pardi D, Verhaegh B, Jonkers D, Pierik M, Münch A, Franke A, Bresso F, Khalili H, Colombel JF, D'Amato M.
Human Leukocyte Antigen Signatures as Pathophysiological Discriminants of Microscopic Colitis Subtypes.
J Crohns Colitis. 2024 Mar 1;18(3):349-359.
DOI: 10.1093/ecco-jcc/jjad165
IF: 8.5

Selected Projects

Development of new oral biologics for Inflammatory Bowel Disease (IBD)
Principal Investigator: Javier santos
Agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 218,513 €
Period: 2023-2026

New tool based on Artificial Intelligence and Biomarkers for early non-invasive diagnosis of Pancreatic Cancer - AI-Early PanC
Principal Investigator: Stephanie Tasayco
Agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 293,321 €
Period: 2023-2026

Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in IRritable bowel syndrome In Europe (DISCOvERIE)
Principal Investigator: JAVIER SANTOS VICENTE
Agency: EUROPEAN COMMISSION H20020
Funding: 1,148,684.84 €
Period: 2020-2025

CFTR down regulation enhances pancreatic carcinogenesis and promotes cancer invasion and metastasis
Principal Investigator: Xavier Molero
Agency: Cystic Fibrosis Foundation
Funding: 300,565.29 €
Period: 2022-2025

Contribución diferencial del epitelio intestinal a la fisiopatología de la diarrea crónica en el síndrome del intestino irritable y la colitis microscópica. Perfil clínico-biológico para el diagnóstico diferencial
Principal Investigator: Guagnozzi, Danila
Agency: Instituto de Salud Carlos III
Funding: 183,920.00 €
Period: 2020-2024

Selected Dissemination Activities

Nit europea de la recerca 2024
Place: Vila Urania, Barcelona
Date: 01/01/1970
Brief: The brain-gut axis and gut microbiota in the origin of symptoms of Irritable Bowel Syndrome, anxiety and depression and fibromyalgia and chronic fatigue syndrome
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Gastro Journal Club
Place: ONLINE
Date: 01/01/1970
Brief: Biofeedback Treatment for Abdominal Distention
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XV Jornadas AEDM. Reunión con pacientes
Place: Sede de la Fundación Once – C/ Sebastián Herrera, 15 – Madrid.
Date: 01/01/1970
Brief: Asociación Española de Mastocitosis y Enfermedades Relacionadas
MORE INFO

VHIR Annual Report 2024