eCORE
- Advanced Therapies and Advanced Interventions, Nanomedicine, Transplant & Donation
- Chronic, Prevalent Diseases & Aging
- Personalized Medicine, Innovative Diagnostics, Molecular Imaging & Digital Health
Team
Group Leader
Oriol Bestard Matamoros, Maria José Soler Romeo
Principal Investigator (PI)
Francesc Moreso Mateos, Maria Antonia Emilia Meneghini, Irina Betsabé Torres Rodríguez, Elena Isabel Crespo Gimeno, Concepció Jacobs Cachá
Researchers
Delphine Kervella, Sheila Bermejo García, Irene Agraz Pamplona, M Antonieta Azancot Rivero, Manel Perelló Carrascosa, Natalia Ramos Terrades, Joana Sellarés Roig, Ander Vergara
PhD Students
Marian López Martínez, Nestor Gabriel Toapanta Gaibor, José Miguel Zuñiga Vergara, Gerson Berná, Claudia Carrera Muñoz, Juan Carlos León Román, Alba Torija Recasens, Laura Donadeu Casassas, Irene Martínez Díaz
Lab Technicians
Franc Casanova Ferrer, Núria Bolaños Peruga, Cristina Guirao Martínez, Mariona Juvé Torres, Cristina Font Miñarro, Carmen Llorens Cebrià
Nursing and Technical Staff
Emma Pardo de los Santos, Maria de Oreto Prat Canet, Alejandro Saiz Domenech, Yi Ji, Rosa Maria Pérez Garzón
Selected Publications
Donadeu, L.; Jouve, T.; Bin, S.; Hartzell, S.; Crespo, E.; Torija, A.; Jarque, M.; Kervella. D.; Zúñiga, J.; Zhang, W.; Sun, Z.; Verlato, A.; Martínez-Gallo, M.; Font-Miñarro, C.; Meneghini, M.; Toapanta, N.; Torres, I.B.; Sellarés, J.; Perelló, M.; Kaminski, H.; Couzi, L.; Loupy, A.; La Manna, G:, Moreso, F.; Cravedi, P.; Bestard, O.
High-dimensional mass cytometry identified circulating natural killer T-cell subsets associated with protection from cytomegalovirus infection in kidney transplant recipients
Kidney International 2024; 27:S0085-2538 (24) 00310-7
DOI: 10.1016/j.kint.2024.03.027
IF: 14.800
Bestard, O.; Augustine, J.; Wee, A.; Poggio, E.; Mannon, R.B.; Ansari, M.J.; Bhati, C.; Maluf, D.; Benken, S.; Leca, N.; La Manna, G.; Samaniego-Picota, M.; Shawar, S.; Concepción, B.P.; Rostaing, L.; Alberici, F.; O’Connell, P.; Chang, A.; Salem, F.; Kattan, M.W.; Donovan, M.I.
Prospective observational study to validate a next-generation sequencing blood RNA signature to predict early kidney transplant rejection
American Journal of Transplantation 2024; 24 (3):436-447
DOI: 10.1016/j.ajt.2023.09.021
IF: 8.900
Torija, A.; Matignon, M.; Vincenti, F.; Casanova-Ferrer, F.; Pilon, C.; Tambur, A.R.; Donadeu, L.; Crespo, E.; Kervella, D.; Meneghini, M.; Torres, I.B.; Hafkamp, F.; Martinez-Lacalle, A.; Carrera, C.; Zúñiga, J.; Brar, A.; Cruzado, J.; Gaber, A.O.; Lee, H.; Montgomery, R.A.; Stegall, M.; Carmagnat, M.; Usureau, C.; Moreso, F.; Grimbert, P.; Bestard, O.
Anti-HLA serologic response to CD38-targeting desensitization therapy is challenged by peripheral memory B cells in highly sensitized kidney transplant candidates
American Journal of Transplantation 2024; 10:S1600-6135(24)00490-8
DOI: 10.1016/j.ajt.2024.08.004
IF: 8.900
Martin, M.; Llorens-Cebria, C.; León-Román, J.; Perurena-Prieto, J.; Perez-Beltran, V.; Saumell, S.; Torres, I.B.; Agraz, I.; Sellarès, J.; Ramos, N.; Bestard, O.; López, M.; Moreso, F.; Ariceta, G.; Soler, M.J.; Hernandez-Gonzalez, M.; Jacobs-Cachá, C.
Ex vivo C5b-9 deposition test to monitor complement activity in clinical and subclinical atypical hemolytic uremic syndrome and in transplantation-associated thrombotic microangiopathy
Kidney International Reports 2024; 9 (7): 2227-2239
DOI: 10.1016/j.ekir.2024.04.022
IF: 5.700
Martos-Guillami, N.; Vergara, A.; Llorens-Cebrià, C.; Motto, A.E.; Martínez-Díaz, I.; Gonçalves, F.; Garcias-Ramis, M.M.; Allo-Urzainqui, E.; Narváez, A.; Bermejo, S.; Muñoz, V.; León-Román, J.; Ferrer-Costa, R.; Jacobs-Cachá, C.; Vilardell-Vilà, J.; Soler, M.J.
SGLT2i and GLP1-RA exert additive cardiorenal protection with a RAS blocker in uninephrectomized db/db mice
Frontiers in Pharmacology 2024; 15: 1415879
DOI: 10.3389/fphar.2024.1415879
IF: 4.400
Selected Projects
RESET INMUNOLÓGICO PARA PERMITIR ACCESO AL TRASPLANTE RENAL HLA COMPATIBLE EN PACIENTES HIPERSENSIBILIZADOS (ENSAYO RESET)
Principal Investigator: Oriol Bestard Matamoros
Agency: Instituto de Salud Carlos III
Funding: 465,456.69 €
Period: 01/09/2024 - 30/08/2028
DUACEPT, A NOVEL BI-SPECIFIC FUSION PROTEIN TO PREVENT TRANSPLANT REJECTION
Principal Investigator: Oriol Bestard Matamoros
Agency: Fundació La Caixa - CaixaImpulse Innovation Programme
Funding: 148,500.00 €
Period: 01/01/2024 - 31/12/2025
DISECCIÓN Y PROMOCIÓN DE INMUNIDAD ADAPTATIVA ESPECÍFICA FRENTE AL POLIOMAVIRUS (BKV) PARA PREVENIR LAINFECCIÓN VIRAL TRAS EL TRASPLANTE RENAL (PROYECTO BK-VAX)
Principal Investigator: Oriol Bestard Matamoros
Agency: Instituto de Salud Carlos III
Funding: 174.240,00 €
Period: 01/01/2023 - 31/12/2025
HORUS, Casting light on HOst-cytomegaloviRUs interaction in Solid organ transplantation
Principal Investigator: Oriol Bestard Matamoros
Agency: European Comission
Funding: 392,651.25 €
Period: 01/11/2022 - 31/10/2027
RESET INMUNOLÓGICO PARA PERMITIR EL ACCESO AL TRASPLANTE RENAL COMPATIBLE EN PACIENTES HIPERINMUNIZADOS
Principal Investigator: Oriol Bestard Matamoros
Agency: Fundación Mutua Madrileña
Funding: 109,725.00 €
Period: 15/09/2023 - 14/09/2025
Patents
Bispecific fusion proteins with immunosuppressive activity
Priority Number: PCT/EP23382404.4
Priority Date: 26 April 2024
Applicants: 100% VHIR
LABORATORY DEVICE FOR COLLECTING OF ANIMAL SAMPLES
Priority Number: 202131356
Priority Date: 29/06/2021
Applicants: 100% VHIR
Diagnosis of allograft rejection
Priority Number: SF-2020-237-1-EP-0,ZBM. Ref: P5489EP00
Priority Date: 2020
Applicants: 100% VHIR
Method for detecting antibody-secreting B cells specific for HLA
Priority Number: 15730984.0-1404
Priority Date: 04.06.2015
Applicants: 100% IDIBELL
Selected Dissemination Activities
World Ronyó Day
Place: VHIR, Barcelona
Date: 01/01/1970
Brief: We perform a global webinar including patients, physicians, nurses and we discuss about important topics on kidney diseases and how to improve quality of life and outcomes
Talk for transplant recipients: post-transplant support applications (DTI)
Place: Barcelona
Date: 01/01/1970
Brief: We present the value of a new digital techonology (Trackyourmed) devoted to help and track chronic medication adherence such as a immunosuppressants together with patients and doctors
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Renal education days (ALCER)
Place: Alcer, Barcelona
Date: 12/12/2024
Brief: It was presented by the PI of the group the main achievements and present and future researchs in the field of kindey transplantation
II Curso CAREME
Place: Hospital Vall d´Hebron
Date: 10/03/2024
Brief: Hospital Clínic & Vall Hebron Course, including the voice of the kidney transplant patient.
Cardiorenometabolic syndrome.
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6ª Jornada de Actualización en Enfermedad Renal Crónica
Place: Hospital del Vall d´Hebron
Date: 01/01/1970
Brief: With the Slogan "We share to improve the care of chronic kidney disease in our region', the Nephrology Service of the Vall d'Hebron University Hospital and the Primary Care and Community of Barcelona city of the ICS have organized, on October 16, 2024, the 6th Update Conference on Chronic Kidney Disease on the Route of the Barcelona Nord Integrated Health Area (AISNORD).
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