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Infection and Immunity in Pediatric Patients

48
Publications
72,92
%Q1
140
Number of citations
55.56
% Open Access Publications
12
Ongoing Projects
0
Number of Presented Theses
16
Number of Active Clinical Trials
We aim to understand the role of the host immune system in response to infections in children addressing both infectious and immunological sides.This year the group has foused its efforts in the development of IA tools to promote early diagnosis of inborn errors of immunity, has elucidated the appropriate antifungal doses to treat invasive fungal infections in children and has publihsed the results of our antimicrobial stewarship program,pioner at an European level. The group has increased the amount and quality of its scientific output using a multidisciplinary approach that promotes translational research focused on improving patients’ quality of life.Several national and international grants and prizes have recognized this value-based approach. Our research is currently developed in the context of several national (RITIP, RECLIP) and international initiatives (EmprEMA, COVIDHGE, JMF) and with active participation of patients and their families allowing a greater scientific outreach.

eCORE

  • Woman & Child Health & Rare Diseases

Team

Group Leader
Pere Soler Palacín

Principal Investigator (PI)
Maria Espiau Guarner, Antoni Soriano Arandes

Researchers
Jacques G. Rivière, Andrea Martin Nalda, Natalia Mendoza Palomar, Susana Melendo Pérez, Antoinette Frick, Jorgina Vila Soler, Núria Worner Tomasa, Aurora Fernández Polo, Laura Roig Soria, Adriana Margarit Soler, Beatriz Álvarez Vallejo, Victoria Rello, Anna Creus Costa, Marina Garcia Prat, Laura Batlle Massó

PhD Students
Alba Parra Martínez

Nursing and Technical Staff
Sonia Galindo Maycas, Claudia Broto Cortés, Laura López Seguer, Sonia Rodríguez Tello, Víctor Carretero Pifarré, Stephany Zelada Márquez, Miriam González Amores

Selected Publications

Riviere JG, Soler Palacin P, Butte MJ.
Proceedings from the inaugural Artificial Intelligence in Primary Immune Deficiencies (AIPID) conference
J Allergy Clin Immunol. 2024 Mar;153(3):637-642.
DOI: 10.1016/j.jaci.2024.01.002
IF: 11.40

Soriano-Arandes A, Colom-Cadena A, Bordas A, Ganem F, Alonso L, Montoro M, Gascon M, Subirana M, Mas A, Sunyer J, Soler-Palacin P, Casabona J
Determinants of school absences due to respiratory tract infections among children during COVID-19 pandemic: A cross-sectional study of the Sentinel Schools Network
Pediatr Pulmonol. 2024 Jan;59(1):236-241
DOI: 10.1002/ppul.26736
IF: 2.7

nandez-Polo A, Melendo-Perez S, Larrosa Escartin N, Mendoza-Palomar N, Frick MA, Soler-Palacin P
Five-Year Evaluation of the PROA-NEN Pediatric Antimicrobial Stewardship Program in a Spanish Tertiary Hospital
Antibiotics (Basel). 2024 May 30;13(6):511.
DOI: 10.3390/antibiotics13060511
IF: 4.30

Domachowske J, Hamren UW, Banu I, Baronio R, Basavaraju B, Koen A, Leach A, Mankad VS, Pannaraj PS, Soler-Palacin P, Takas T, Mori M, Villafana T
Safety and Pharmacokinetics of Nirsevimab in Immunocompromised Children.
Pediatrics. 2024 Oct 1;154(4):e2024066508
DOI: 10.1542/peds.2024-066508
IF: 6.20

Riviere JG, Carot-Sans G, Piera-Jimenez J, de la Torre S, Cos X, Serra-Picamal X, Soler-Palacin P, Alsina L, Bielsa Masdeu AM, Bosom Diumenjo M, Carbone J, Carreras C, Deya-Martinez A, Dieli-Crimi R, Espiau M, Fernandez Pereira L, Gonzalez I, Juan M, LLobet P, Martin-Nalda A, Mendez M, Neth O, Ocejo-Vinyals JG, Olbrich P, Rodriguez JC, Rodriguez-Vigil Itur, Rodrigo C, Santos Perez JL
Development of an Expert-Based Scoring System for Early Identification of Patients with Inborn Errors of Immunity in Primary Care Settings - the PIDCAP Project.
J Clin Immunol. 2024 Oct 21;45(1):26
DOI: 10.1007/s10875-024-01825-3
IF: 7.20

Selected Projects

RBDCOV: RBD Dimer recombinant protein vaccine against SARSCoV2
Principal Investigator: Pere Soler Palacin
Agency: European Commission H2020
Funding: 395,000 €
Period: 2021-2025

RECOMB: Stem-cell based gene therapy for recombination deficient SCID
Principal Investigator: Pere Soler Palacin
Agency: European Commission H2020
Funding: 57,500 €
Period: 2018-2024

UNDINE: The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalized medicine
Principal Investigator: Pere Soler Palacin
Agency: European Commission H2020
Funding: 312,525 €
Period: 2022-Ongoing

Phase IV, randomized, open label, parallel groups clinical trial for evaluating the early Stop of antibiotic Treatment in febrile neutropenic Oncohaematological Paediatric patients (eSTOP-study).
Principal Investigator: Pere Soler Palacin
Agency: Instituto Carlos III (ISCIII)
Funding: 135,520 €
Period: 2020-2024

IEI-HAEM: The interplay between Inborn Error of Immunity and blood disorders: unravelling immune defects behind common haematological diseases.
Principal Investigator: Pere Soler Palacin
Agency: European Joint Programme Rare Diseases
Funding: 1,639,202 €
Period: 2023-Ongoing

Patents

PIDCAP (Early detection of primary immunodeficiencies in Primary Care)
Priority Number: 1908021605053
Priority Date: 29/07/2019
Applicants: Pere Soler Palacín, Jacques Riviere (50% for each inventor). Applicant entity: Fundació Institut de Recerca de l'Hospital Universitari Vall d'Hebron.

Play PROA (Training by gamification in pediatric antimicrobial stewardship programs).
Priority Number: 1907251526961
Priority Date: 05/08/2019
Applicants: Pere Soler Palacín, Aurora Fernández Polo, Susana Melendo Pérez. Applicant entity: Fundació Institut de Recerca de l'Hospital Universitari Vall d'Hebron.

Selected Dissemination Activities

Experience of universal programs on neonatal screening for SCID in spain
Place: Online (Barcelona)
Date: 01/01/1970
Brief: Dr. Andrea Martín will coordinate the first round of neonatal screening programs from the IDCG to the Spanish State aimed at both professionals and patients and families.

TPH Day
Place: Hospital Vall d'Hebron (Barcelona)
Date: 01/01/1970
Brief: Our group organized a day dedicated to the evaluation of immune reconstitution after transplantation of hematopoetic progenitors with the participation of renowned international speakers.
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International Day of Women and Girls in Science
Place: Escola Guerau de Liost (Les Franqueses del Vallès)
Date: 02/09/2024
Brief: The team's research coordinator, Miriam González, attended at the Escola Guerau de Liost in Les Franqueses del Vallès (Catalonia) to share our personal experience in the world of science.

International Day of Women and Girls in Science
Place: Institut Narcís Xifra of Girona (Catalonia)
Date: 02/11/2024
Brief: The postdoc researcher, Laura Batlle, attended at Institut Narcís Xifra of Girona (Catalonia) to share our personal experience in the world of science.

Visit to the primary immunodeficiency research laboratory
Place: Vall d'Hebron Institute of Research (VHIR)
Date: 01/01/1970
Brief: On June 18th, a group of 18 students of the University of Central Florida (EEUU) visited our immunology lab with the API abroad exchange program. Alba Parra (pre-doctoral resercher) and Miriam González (research coordinator) shared with the students their daily day on the laboratori of Advanced studies in immunodeficiències.
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VHIR Annual Report 2024