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Headache and Neurological Pain

38
Publications
89.47
%Q1
163
Number of citations
67.65
% Open Access Publications
8
Ongoing Projects
2
Number of Presented Theses
27
Number of Active Clinical Trials
Our group has continued to work on our main overarching project the Migraine Adaptive Brain Program (MAB). During 2024 our research has focused on 3 main areas: preclinical, translational and clinical. - Animal Brain & Cell Adaptive Lab: we have developed a project to understand the relationship between depression and migraine. We have started a project to understand the function of glial cells in animal migraine models. - Gene-Environment Lab: we have continued to work on our epigenetic, transcriptomic and molecular research, which is focused on disease diagnosis and target-driven therapeutics - Sense, Rhythm & Connectivity Lab: we have focused on understanding the neurosensorial responses of migraine. - Clinical MAB program: we have worked on several clinical trials and 5 large investigator-driven projects. We have initiated and/or participated in 33 clinical trials in adults, adolescents and children, testing 8 different active drugs. We have published 40 peer-reviewed papers.

eCORE

  • Brain & Mind and Behaviour
  • Chronic, Prevalent Diseases & Aging
  • Woman & Child Health & Rare Diseases

Team

Group Leader
Patricia Pozo Rosich

Principal Investigator (PI)
Marta Torres-Ferrus, Marta Vila-Pueyo

Researchers
Edoardo Caronna, Victor J Gallardo, Alicia Alpuente, Nara Ikumi

PhD Students
Joana Rosell Miami, Otilia Gliga, Rut Mas de les Valls

Lab Technicians
Laila Asskour

Nursing and Technical Staff
Eulalia Giné Ciprés, Raquel Lastra, Estefania Muñoz

Selected Publications

Caronna E, Gallardo VJ, Egeo G, Vázquez MM, Castellanos CN, Membrilla JA, Vaghi G, Rodríguez-Montolio J, Fabregat Fabra N, Sánchez-Caballero F, Jaimes Sánchez A, Muñoz-Vendrell A, Oliveira R, Gárate G, González-Osorio Y, Guisado-Alonso D, Ornello R, Thunstedt C, Fernández-Lázaro I, Torres-Ferrús M, Alpuente A, Torelli P, Aurilia C, Pére RL, Castrillo MJR, Icco R, Sances G, Broadhurst S, Ong HC, García AG, Campoy S, Sanahuja J, Cabral G, Beltrán Blasco I, Waliszewska-Prosół M, Pereira L, Layos-Romero A, Luzeiro I, Dorado L, Álvarez Escudero MR, May A, López-Bravo A, Martins IP, Sundal C, Irimia P, Lozano Ros A, Gago-Veiga AB, Juanes FV, Ruscheweyh R, Sacco S, Cuadrado-Godia E, García-Azorín D, Pascual J, Gil-Gouveia R, Huerta-Villanueva M, Rodriguez-Vico J, Viguera Romero J, Obach V, Santos-Lasaosa S, Ghadiri-Sani M, Tassorelli C, Díaz-de-Terán J, Díaz Insa S, Oria CG, Barbanti P, Pozo-Rosich P (CA); EUREkA study group
Redefining migraine prevention: early treatment with anti-CGRP monoclonal antibodies enhances response in the real world
J Neurol Neurosurg Psychiatry 2024;95:927-937
DOI: 10.1136/jnnp-2023-333295
IF: 8.800

Pozo-Rosich P (CA), Dolezil D, Paemelaire K, Stephen A, Stude P, Snellman J, Arkuszewski M, Stites T, Ritter S, Lopez Lopez C, Maca J, Ferraris M, Gil-Gouveia R.
Early use of erenumab vs nonspecific oral migraine preventives. The APPRAISE randomized clinical trial
JAMA Neurology 2024:81(5):461-470
DOI: 10.1001/jamaneurol.2024.0368
IF: 20.900

Pozo-Rosich P (CA), Alpuente A, Silberstein SD, Burstein R
Insights from 25 years of onabotulinumtoxinA in migraine – mechanisms and management
Nat Rev Neurol 2024;20:555-568
DOI: 10.1038/s41582-024-01002-5
IF: 28.2

Lazaro-Hernandez C, Caronna E, Rosell-Mirmi J, Gallardo VJ, Alpuente A, Torres-Ferrus M, Pozo-Rosich P (CA
Early and annual projected savings from anti-CGRP monoclonal antibodies in migraine prevention: a cost-benefit analysis in the working-age population
Journal Headache Pain 2024;25:21
DOI: 10.1186/s10194-024-01727-0
IF: 7.300

Torres- Ferrus M, Gallardo VJ, Alpuente A, Caronna E, Gine-Cipres E, Pozo-Rosich P (CA)
Improvement of migraine depressive symptoms is not related to headache frequency: exploring the impact of anti-CGRP therapies
Cephalalgia 2024;44:3331024231222923
DOI: 10.1177/03331024231222923
IF: 5.000

Selected Projects

PREDIMIGRAINE: Medicina de precisión para prevenir la cronificación de la migraña a través de la predicción de las crisis de dolor y de la respuesta al tratamiento con anticuerpos anti- CGRP utilizando estrategias multi-ómicas
Principal Investigator: Patricia Pozo-Rosich
Agency: Instituto Salud Carlos III – PMP22/00189
Funding: 377,633.30€
Period: 2022-2025

FAST: Fenotipado molecular de pacientes con migraña según edad y sexo a través de la cuantificación de CGRP en saliva para realizar medicinad de precisión
Principal Investigator: Patricia Pozo-Rosich
Agency: Instituto Salud Carlos III – ISCIII (AES) – PI22/01501
Funding: 81,070€
Period: 2022-2025

BIOMIGA: A multidisciplinary approach to the identification of BIOmarkers of MIGraine: a proof of concept study based on the stratification of responders to CGRP monoclonal Antibodies
Principal Investigator: Patricia Pozo-Rosich
Agency: Instituto de Salud Carlos III/ERANet Neuron – AC19/00124
Funding: 175,000€
Period: 2020-2024

MAMBO:BiOmarcadores Moleculares y clínicos de respuesta al tratamiento en los Ataques de Migraña
Principal Investigator: Marta Torres-Ferrus
Agency: Instituto Salud Carlos III
Funding: 78,000€
Period: 2022-2025

Study of the glia in an animal model of migraine
Principal Investigator: Marta Vila-Pueyo
Agency: la Caixa Junior Leader
Funding: 305,000€
Period: 2024-2026

Selected Dissemination Activities

Awareness Webinars
Place: Online
Date: 26/07/2025
Brief: Our research group organizes webinars to inform society and people with headache and migraine about the disease, research and therapeutic options

VHIR Annual Report 2024