Head and Neck Cancer: Biomedical Research Cancer Stem cells

Publications

40.00

%Q1

Number of citations

40.00

% Open Access Publications

Ongoing Projects

Number of Presented Theses

Number of Active Clinical Trials

Basic research: we have continued in the characterization of new compounds able to block proteins involved in cancer resistance such as TSPAN1, SDCBP or SFN. Regarding TSPAN1, we have determined the role of drug D14-3 both in cells and mice in the inhibition of HNSCC model. Moreover, we have designed new drug variants (medicinal chemistry) with higher potency than the original drugs from in silico models that have been tested in vivo and in vitro. Clinical research: the ORL Service of Vall d'Hebron Hospital has been reorganised by subspecialties, with advanced clinical units. Robotic surgery has been developed, 3D planning in head and neck surgery. A programme of cochlear implants and lateral skull base in otology. Collaboration with neurosurgery in transnasal surgery and polyposis trials. In childrens an airway unit has been created and multidisciplinary committees have been set up, strengthening teaching, innovation and translational research.

eCORE

Cancer
Global Health

Team

Group Leader
Matilde E. LLeonart and David Virós

Principal Investigator (PI)
Matilde E. LLeonart

Researchers
Yoelsis García-Mayea, Almudena Sánchez García, Laura Grau de Diego, Sílvia Naches Solsona, Juan Fernando Fuentes, Pablo Vergés, David Virós, Matilde E. LLeonart

PhD Students
Marina Bataller Fernández, Gaomiyang Liu, Yang Hong

Selected Publications

Paciucci R, Carnero A, LLeonart ME.
Editorial: Reciprocal crosstalk between the tumor microenvironment and cancer stem cells.
Front Immunol. 2024 Nov 5;15:1505225.
DOI: 10.3389/fimmu.2024.1505225
IF: 5.7

Albert Pujol , Xavier León , Anna Holgado , Cristina Valero , Katarzyna Kolanczak, Miquel Quer, David Virós
External validation of the GETTEC algorithm for elective neck dissection in patients candidates for salvage total laryngectomy
Oral Oncol
DOI: 10.1016/j.oraloncology.2024.106686
IF: 4

Llansana, A; Viros Porcuna, D; Vasquez, R; Parellada, A; Valero, C; Holgado, A; Leon, X
PATH classification: a proposal for patients with HNSCC treated with salvage surgery.
European Archives of Oto-Rhino-Laryngology. Springer. 282-2, pp.971-979.
DOI: 10.1007/s00405-024-08961-x
IF: 1.9

Viros Porcuna, D (AC); Pollan Guisasola, CM; Viña Soria, C; Verges Fort, P; Palau Viarnes, M; Juesas Iglesias, L; De Virgilio, A
Transoral Robotic Parapharyngeal Space Dissection
Head & Neck. Wiley. 46-10, pp.2657-266.
DOI: 10.1002/hed.27902
IF: 2.4

De Virgilio, A; Viros Porcuna, D; Sampieri, C; Constantino, A.
Is the robot an instrument or an indication for transoral surgery?
2024. Oral Oncology. Elsevier. 153, pp.106716.
DOI: 10.1016/j.oraloncology.2024.106716
IF: 4

Selected Projects

“New therapeutic approaches in head and neck cancer”
Principal Investigator: Matilde E. LLeonart
Agency: Ministerio de Salud Carlos III
Funding: 183,920 €
Period: 2021-2025

Novel therapeutic approaches against COVID-19
Principal Investigator: Matilde E. LLeonart
Agency: La Marató TV3
Funding: 161,875 VHIR (297,000 € whole consortium)
Period: 2022-2024 (3y)

New compounds targeting head and neck cancer as Trojan horses against chemoresistant cells
Principal Investigator: Matilde E. LLeonart
Agency: Agaur
Funding: 20,000 €
Period: 2024 (6m)

Patents

“COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS THAT OVEREXPRESS TSPAN1”
Priority Number: EP23383269
Priority Date: 10/12/2024
Applicants: 60% VHIR, 20% URiV, 20% IQAC-CSIC

Selected Dissemination Activities

Visites escolars en el Dia de les nenes, les dones i la ciència
Place: VHIR
Date: 02/11/2024
Brief: Visit of children from High School to visit our laboratory
MORE INFO

EscoLab
Place: VHIR
Date: 04/10/2024
Brief: VIsit of teenagers from High School to our laboratory
MORE INFO

Visit associatted to the Marato TV3 Project
Place: VHIR
Date: 06/04/2024
Brief: Disseminnation video promoted by La Marató TV3 Foundation
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International Day of Head and Neck cancer
Place: HUVH
Date: 01/01/1970
Brief: Organization of a stand at the entrence of the HUVH with disseminnation activites for patients and families
MORE INFO