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Clinical Pharmacology

20
Publications
70.00
%Q1
13
Number of citations
90.00
% Open Access Publications
3
Ongoing Projects
2
Number of Presented Theses
8
Number of Active Clinical Trials
The main research field of the group is pharmacoepidemiology and pharmacovigilance, with a special focus on the patterns of medicines utilization, effectiveness and adverse effects in usual clinical practice. The group is a partner of the European Consortium EU PE&PV Network. It is also part of the ENCePP, coordinated by the EMA. We have been focused our interest on advanced therapies and during 2024 we finished a multicenter project on the late sided effects in patients treated with CAR-T cell therapy. Other projects we have been collaborating on: 1) in the GCoVS study aimed at assessing pharmacogenetic variants related to Guillain-Barre syndrome, thrombosis-thrombocytopenia and miopericarditis in COVID-19 vaccinated patients and 2) in the use of TARGET-Trial emulation methodology for regulatory decisions. Finally, our group has continued its participation in the European pharmacoepidemiology master (Eu2P) and hosting fellow researchers. It is also part of the UAB Research Park.

eCORE

  • Advanced Therapies and Advanced Interventions, Nanomedicine, Transplant & Donation
  • Global Health

Team

Group Leader
Maria Antònia Agustí Escasany

Principal Investigator (PI)
Immaculada Danés Carreras, Mònica Sabaté Gallego, Cristina Aguilera Martín

Researchers
Montserrat Bosch Ferrer, Lina Camacho Arteaga, Eduard Diogène Fadini, Eulàlia Pérez Esquirol, Elena Ballarín Alins, Lourdes Vendrell Bosch, Angela Mesas Idáñez, Francisco Javier Medel

PhD Students
Carla Sans Pola, Judit Riera Arnau, Carolina Iglesias López, Kristopher Amaro Hosey, Lina Leguizamo Martínez, Gustavo Molina Molina, Elena Guillen Benítez, Emilie Anderssen Nordalh, Manuel Machado, Lucia Bellas Fernández, Daniel Wang, Marta Merino Castelló

Selected Publications

Onken M, Lohse L, Coulm B, Beghin D, Richardson JL, Bermejo-Sánchez E, Aguilera C, Bosch M, Cassina M, Chouchana L, De Santis M, Duman MK, Gören MZ, Johnson D, Bera APJ, Kaplan YC, Kennedy D, Kwok S, Lacroix I, Lepelley M, Pistelli A, Schaefer C, Te Winkel B, Uysal N, Winterfeld U, Yakuwa N, Diav-Citrin O, Vial T, Dathe K.
Effects of maternal modafinil treatment on fetal development and neonatal growth parameters - a multicenter case series of the European Network of Teratology Information Services (ENTIS)
Acta Psychiatr Scand. 2024 Nov;150(5):372-384.
DOI: 10.1111/acps.13643.
IF: 5.3

Molina-Molina GJ, Garnica Velandia DR, Andrés-López B, Perales C, Marin-Asensio L, Jurgens Y, Esteso O, Escobar C, Vidal X, Vendrell L, Gómez-Ganda L, Rodríguez D, Montané E, Cardona V, Agustí A.
Delabelling beta-lactam allergy.
Front Pharmacol. 2024 Jun 27;15:1423719.
DOI: 10.3389/fphar.2024.1423719
IF: 4.4

Anderssen-Nordahl E, Fernández-Liz E, Sabaté Gallego M, Bosch Ferrer M, Sánchez-Arcilla Rosanas M, Cervera León M, Magrinyà JM, Barceló-Colomer ME.
The impact of a multidisciplinary team intervention on medication prescription in nursing homes in Catalonia.
Front Pharmacol. 2024 Sep 13;15:1445141.
DOI: 10.3389/fphar.2024.1445141.
IF: 4.4

Riera-Arnau J, Ballarin E, Llop R, Montane E, Hereu P, Vancells G, Padulles-Zamora N, Barriocanal AM, Cardona-Peitx G, Casasnovas C, Montoro JB, Nunez M, Santacana Juncosa E, Selva-O'Callaghan A, Solanich X, Sabate Gallego M
Use of non-specific immunoglobulins in Catalonia in three third-level hospitals: a descriptive analysis of a hospital-prescribed medication registry.
Front Pharmacol. 2024 Dec 16;15:1420682
DOI: 10.3389/fphar.2024.1420682.
IF: 4.4

Bellas L, Camacho-Arteaga L, Giner-Soriano M, Prats-Uribe A, Aguilera C, Vedia Urgell C, Agusti A
Women's health in focus: Real-world data on valproate prescriptions during pregnancy - a cohort study in Catalonia (Spain).
BMJ Open. 2024 Aug 12;14(8):e085167.
DOI: 10.1136/bmjopen-2024-085167.
IF: 2.4

Selected Projects

Genomics of COVID-19 vaccine-induced GBS, VITT/TTS and miocarditis/pericarditis
Principal Investigator: Xavier Martínez and Mònica Sabaté
Agency: US CDC Promotor: VAC4EU (GVDN)
Funding: 10,000$+3,000$+100$case+20$control from US CDC
Period: 2022-2025

A framework for the post-authorisation safety monitoring and evaluation of vaccines in EU. SAFETY-VAC (EMA/2020/46/TDA/18, Lot 5)
Principal Investigator: Carlos Durán
Agency: European Medicines Agency
Funding: 1,000,000 € for the whole project
Period: 2023-2024

Use of antiepileptics, and feasibility of studies on the association between maternal and paternal exposure to antiepileptics and risk of adverse pregnancy, neonatal and child outcome. ADEPT (EMA/2020/46/TDA/20, Lot 5)
Principal Investigator: Miriam Sturkenboom
Agency: European Medicines Agency
Funding: 750,000€ (VHIR 3,630€)
Period: 2024-2026

Comparative effectiveness and safety studies using the target trial emulation and estimand frameworks. TARGET EU (EMA/2020/46/TDA/19, Lot 5).
Principal Investigator: Olaf Klungel, Colider 1rst work-package Mònica Sabaté
Agency: European Medicines Agency
Funding: 998,000€ (VHIR: 49,500€)
Period: 2024-2026

Uso de fármacos en mujeres embarazadas y lactantes. Consecuencias en la salud de estas mujeres y en la de su descendencia.
Principal Investigator: Cristina Vèdia - Lina Camacho
Agency: PERIS- Departament de Salut, Generalitat de Catalunya SLT021/21/000068
Funding: All project 150,964,95 € (VHIR 4,500 €)
Period: 2022-2024

Selected Dissemination Activities

2a diada FARMACOVIGILANT
Place: Acadèmia de Ciències Mèdiques de Barcelona
Date: 01/01/1970
Brief: Several medical residents from the service comment on several cases of adverse drug reactions to the audience.
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16th Congress of EACPT 2024 – Rotterdam, June 8th-11h
Place: Rotterdam
Date: 06/08/2024
Brief: A research from our group commented on several scientific and other kind of activities developed during the year for the Young Clinical pharmacology group.
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Jornades doctorals 2024_Societat Catalana de Farmacologia
Place: Barcelona, Acadèmia de ciències Mèdiques
Date: 01/01/1970
Brief: A PhD research communicated the full results of one study of her PhD project.
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VHIR Annual Report 2024