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Biomedical Research in Gynecology

29
Publications
75.86
%Q1
49
Number of citations
47.62
% Open Access Publications
20
Ongoing Projects
2
Number of Presented Theses
3
Number of Active Clinical Trials
During this year, we highlight the upgrade of three of our members to principal researchersValeria Tubita, postdoctoral researcher, was granted with a Dexeus 2024 grant for the “Preclinical study of anti-HER2 therapies and PARP inhibitors in endometrial cancer”. This project, together with the growing expansion of the GynePDX platform of patient-derived preclinical models, strengths our research in personalized medicine for gynaecological diseases. Dr. Melissa Bradbury, clinical associate of the group, was granted as co-PI  with Dr. Gil a national project which aims to research on proteomic signatures and therapeutic alternatives for platinum-resistant ovarian cancer patients. Dr. Vicente Bebia, clinical associate, was also granted with a La Marató TV3 project as principal researcher to develop clinical research to improve the quality of life in gynaecological cancer patients. Altogether, we achieved a stronger positioning in all research lines and team during this 2024.

eCORE

  • Cancer

Team

Group Leader
Antonio Gil Moreno, Eva Colàs

Principal Investigator (PI)
Antonio Gil Moreno, Eva Colás Ortega, Silvia Cabrera Díaz, Melissa Bradbury

Researchers
Cristian Moiola, Carlos López, Javier de la Torre, Martín Espinosa, Assumpció Pérez Benavente, Cristina Centeno, Martina Angeles Fité, Vicente Bebia, Anna Luzarraga, Laura Mañalich, Elena Suárez, Montse Cubo, Sonia Monreal, Diana Guerrero, Ursula Acosta, Josep Castellvi, Angel García, Carme Dinarés, Anna Ruano, Sabina Salicrú, Christian Sisó

PhD Students
Carina Masferrer, Beatriz Villafranca, Melek Denizli, Irene de la Calle, Raquel Delgado

Lab Technicians
Marta Rebull, Francesc Serra

Nursing and Technical Staff
Elisabeth Olivan

Selected Publications

Aznar AL, Canton R, Loren G, Carvajal J, de la Calle I, Masferrer-Ferragutcasas C, Serra F, Bebia V, Bonaldo G, Angeles MA, Cabrera S, Palomar N, Vilarmau C, Martí M, Rigau M, Colas E, Gil-Moreno A.
Current challenges and emerging tools in endometrial cancer diagnosis.
Int J Gynecol Cancer. 2024 Dec 18:100056
DOI: 10.1016/j.ijgc.2024.100056
IF: 4.1

Casas-Arozamena C, Vilar A, Cueva J, Arias E, Sampayo V, Diaz E, Oltra SS, Moiola CP, Cabrera S, Cortegoso A, Curiel T, Abalo A, Pamies Serrano M, Domingo S, Padilla-Iserte P, Arnaez de la Cruz M, Hernández A, García-Pineda V, Ruiz-Bañobre J, López R, Matias-Guiu X, Colás E, Gil-Moreno A, Abal M, Moreno-Bueno G, Muinelo-Romay L.
Role of cfDNA and ctDNA to improve the risk stratification and the disease follow-up in patients with endometrial cancer: towards the clinical application.
J Exp Clin Cancer Res. 2024 Sep 20;43(1):264.
DOI: 10.1186/s13046-024-03158-w
IF: 11.4

Cabrera S, Bebia V, López-Gil C, Luzarraga-Aznar A, Denizli M, Salazar-Huayna L, Abdessayed N, Castellví J, Colas E, Gil-Moreno A.
Molecular classification improves preoperative risk assessment of endometrial cancer.
Gynecol Oncol. 2024 Oct;189:56-63.
DOI: 10.1016/j.ygyno.2024.07.003
IF: 4.5

Luzarraga Aznar, A., Bebia, V., López-Gil, C., Villafranca-Magdalena, B., Salazar-Huayna, L., Castellvi, J., Colàs, E., Gil-Moreno, A., & Cabrera, S.
Molecular profile is a strong predictor of the pattern of recurrence in patients with endometrial cancer.
International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society, 2024 May 6; 34(5), 659–666.
DOI: 10.1136/ijgc-2023-005165
IF: 4.5

Bonaldo G, De Vitis LA, Pérez-Benavente A, Gil-Moreno A, Multinu F.
Pocket reference based on the International Federation of Gynecology and Obstetrics (FIGO) staging of endometrial cancer 2023.
Int J Gynecol Cancer. 2024 Dec 2;34(12):1993-1995
DOI: 10.1136/ijgc-2024-005826
IF: 4.1

Selected Projects

Desarrollo de un test no invasivo para el diagnóstico de cáncer de endometrio basado en la detección de marcadores proteicos en biopsia líquida cervical. (PI23/01470)
Principal Investigator: Eva Colás
Agency: Instituto de Salud Carlos III
Funding: 177,500 €
Period: 2024-2026

CytoMARK: Development of a personalised non-invasive diagnosis of endometrial cancer using proteomic markers in cervical fluids and clinical data. (ERAPERMED2021-146_CytoMARK)
Principal Investigator: Eva Colás
Agency: Instituto de Salud Carlos III, Asociación Española Contra el Cáncer
Funding: 824,933 €
Period: 2022-2025

ScreenEC: Development of a non-invasive IVD for endometrial cancer screening on high-risk populations. (CPP2022-009817)
Principal Investigator: Eva Colás
Agency: Ministerio de Ciencia e Innovación
Funding: 1,506,847 € (VHIR 210,920 €)
Period: 2023-2026

Desarrollo de CEMARK-Px, un método in vitro para el diagnóstico objetivo y preciso del tipo y grado histológico del cáncer de endometrio en fluido uterino. (DTS23/00091)
Principal Investigator: Eva Colás
Agency: Instituto de Salud Carlos III
Funding: 278,300 €
Period: 2023-2025

ScreenEC, validació d’una eina de triatge no invasiu en càncer d’endometri. (SLT036/24/000059)
Principal Investigator: Eva Colás
Agency: Generalitat de Catalunya
Funding: 99,946 €
Period: 2024-2025

Patents

Biomarkers for endometrial cancer Spain
Priority Number: EP21382680.3
Priority Date: 23/07/2021
Applicants: 80% VHIR / 20% LIH

Markers for endometrial cancer
Priority Number: PCT/EP2018/069841
Priority Date: 21/07/2017
Applicants: 100% VHIR

Markers of endometrial cancer
Priority Number: PCT/EP2017/057635
Priority Date: 04/05/2016
Applicants: 100% VHIR

Selected Dissemination Activities

ENDO-HIT project
Place: High schools in Barcelona
Date: 01/01/1970
Brief: Programme as part of the Caixa d'eines/Pla de Barris citizen science co-creation programme. As part of the ENDO-HIT project, researchers from the team went to schools to raise awareness of menstrual health and inform about endometriosis and associated pain. In addition, information was collected from students on demographics, knowledge of endometriosis, and the impact and importance of the talk. Specifically, these two schools conducted co-creation activities related to the talk in which they actively participated, and made an analysis of the data from the questionnaires.
MORE INFO

EscoLAB
Place: VHIR
Date: 04/10/2024
Brief: Programme organised by Barcelona City Council in which different schools visited the Biomedical Research Group to get in touch with our team and learn about the lines of research we carry out.
MORE INFO

CONÓCELAS
Place: Barcelona schools
Date: 01/01/1970
Brief: Programme promoted by ASEICA, one of the largest cancer research associations in our country. In this programme a group of women scientists connect with institutes at national level to explain and promote STEM careers in institutes.
MORE INFO

International Day of Women and Girls in Science
Place: Barcelona schools
Date: 26/07/2025
Brief: Researchers from the group went to schools to explain the importance of the day, raise awareness of menstrual health and inform about endometriosis and associated pain. Information was also collected from pupils on demographics, knowledge of endometriosis, and the impact and importance of the talk.

Dissemination of the results of our research in the media
Place: VHIR
Date: 26/07/2025
Brief: In recent years, there has been active dissemination both in television programmes (the group's research was one of the topics covered in TV3's Càpsules) and in print and digital newspapers (La Vanguardia, La Razón, etc); radio (Cadena Ser, etc); websites (lavozdigital.es); and social networks (Twitter, LinkedIn).

VHIR Annual Report 2024